Global Leading Company- Developing Drugs Derived from Natural Products for Chronic Wound Healing
Pipeline inProgress(February 2017 - present)
Pressure Ulcer: Laboratory and animal experiments for identifying lead candidates and evaulating the mechanism of the healing effect of PUPre-Clinical Trials in 2018
Plans to initiate Clinical Phase 1 study in 2019
Evaluation of candidates for Foot Ulcer drug, in vitro experiments (in progress)
Evaluation of candidates for Muscular loss, in vitro experiments (in progress)
Non-healing or Chronic wound or age-related chronic inflammation,
Causes of Pressure Ulcer
Pressure ulcers, also called bed sores or pressure sores, are injuries to the skin and underlying tissue resulting from prologed pressure on the skin. It most often develops on skin that covers bony areas of the body, such as heels, ankles, hips, and the tailbone.
Pressure ulcers frequently occur in groups of people having reduced mobility who were hospitalized for long periods of time and elderly or disabled people who cannot move certain body parts without help.
PU is a secondary disease which occurs from ischemic due to insufficient blood circulation, caused by pressure on the bony parts of the body.
Because over 70% of PU mainly occurs in elderly people, who have a high risk for it, PU could be categorized as an age-related and metabolic disease, but also as a neurological disorders (dysfunction), particularly for disabled people with paralysis under 65 years of age.
Stages of Pressure Ulcers
Pressure ulcers (PU) are staged to indicate the extent of tissue damage. The National Pressure Ulcer Advisory Panel (NPUAP) established a staging system for categorizing pressure ulcer injuries. Prolonged unrelieved pressure leads to ischaemia when tissue compression exceeds capillary pressure. At stage 1, PU presents with intact and erythematous skin that does not blanch, but PU appear as a fluid-filled blister at stage 2. At stage 3, necrosis results from tissue hypoxia and ischaemia-reperfusion injury with wound exudate. At stage 4, the ulcer is much deeper and extends into bone or muscle with full tissue loss.
Needs of New Drug for Pressure Ulcer
Optimization of controllable healing factors, like clearance of infection and mechanical protection, have mainly been used thus far.
Few targeted treatments have been developed to date, including topical application of growth factors such as bFGF, VEGF, PDGF, EGF; unfortunately, with limited clinical efficacy and frequent side effects.
All are rectricted to treating non-healing wounds, which creates significant economic burdens in the health care system.
There is a need for the development of aggressive and safe treatment and a curable drug for non-healing wounds like PU and Foot Ulcers.
There are 6 types of wounds, which are classified depending on their causes.
Bruise is appears on the skin due to blunt trauma. The injury causes tiny blood vessels called capillaries to burst and blood gets trapped below the skin’s surface, which causes a bruise.
Abrasions occurs when the skin rubs or scrapes against a rough surface.
Puncture is a small hole caused by a ice pick, nail, and stick(of tree)
Incisions are caused by sharp knife, shard of glass and razor blade (operation)
Avulsions is a partial or complete tearing away of skin and tissue, which is caused by body-crushing accidents, gunshots and explosions.
Laceration is a deep cut or tearing of the skin, which is caused by accidents with knives and machinery.
Source : Info Doctor 제352호, 2005.12. GlobalData. Wound Closure Device - Global Pipeline Analysis. Competive Landscape and Market Forecast to 2018
The wound healing process can be divided into 4 distinct phases, which has been denoted as hemostasis, inflammatory, proliferation, and remodeling.
|Inflammatory||Proliferation||Matrix Formation and Remodering|
|foreign materials, bacteria, bridgement of necrotic tissue, recruiting immune celss from the circulation to the wound site.||synthesis of collagen type III increase of wound tensil strength and formation of scar.||fibronectin, hyaluronic acid, proteogycan, local deposition of collagen type III deposition of collagen type I.|
Source : GlobalDate. Wound Closure Devices - Global Pipeline Analysis, Competitive Landscape and Market Forecasts to 2018